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-0.06 re /F12 1 Tf 450.36 574.92 l 283.08 269.76 l 162.84 256.2 1.68 -0.06 re 418.44 223.56 l 505.68 424.68 0.84 -0.06 re 484.56 298.08 l S 370.68 540.84 l 166.44 643.08 l 1 g 223.56 339.24 l f* f* 329.76 233.4 l 446.52 408.24 l 296.76 526.44 l ET 355.08 580.8 l 318.6 154.08 l 309.96 303.84 1.68 -0.06 re 0 G 259.8 269.28 l S 180 574.68 l 259.32 174.72 l 0 g f* 219.24 257.64 l 345 570.12 l f* 128.16 253.32 l f* 152.88 233.64 l 1 g 180 302.4 1.08 -0.06 re 175.68 354.424 172.454 351.36 168.48 351.36 c 304.56 246.84 l f* S Q 359.52 229.8 l 207.24 566.16 l q f* 259.32 255.24 l 254.76 552.6 l 0.075 0.271 0.8 rg 257.76 204.6 l 164.16 538.92 m 488.16 437.64 l 160.56 448.68 l 294.24 545.76 l 330.96 619.56 l f* -0.005 Tw 291.12 542.52 l 251.76 224.16 l 475.68 249 l 412.68 307.8 l 266.16 635.16 m 181.56 572.64 l 367.68 204.96 l 160.56 356.88 l 1 g 165.12 462.72 l 271.192 271.68 278.88 264.046 278.88 254.64 c 444.12 142.8 l 278.52 150.36 m 313.92 229.68 m 431.76 548.88 l 170.88 539.52 l 420.24 621.72 l 183.12 565.8 l f* 153.84 258 1.68 -0.06 re 1 g f* 305.76 235.44 l 340.758 564.48 332.64 572.598 332.64 582.6 c 438.12 176.52 l 272.16 170.76 l 191.04 355.2 l 242.64 249 l 291.48 565.8 l 297.12 234.6 l 206.16 571.92 l 407.16 595.44 l 406.2 595.44 l 398.88 163.44 l 152.16 601.44 l 376.2 301.92 0.36 -0.06 re /F6 1 Tf 208.8 276.6 l 208.8 584.4 l 200.76 535.8 l 342.36 614.76 l 180.6 415.8 l S 157.44 510.84 l f* 333.24 511.44 l 275.4 187.08 l 317.16 539.52 l 208.8 652.68 l 288.24 269.52 l 429.96 447.72 l 331.44 246 l BT 440.04 537.6 l f* 221.4 519.48 l 164.88 176.76 6 -2.76 re S 258.96 152.16 l S f* 247.92 599.52 l 380.04 576.96 l 178.08 520.8 l 317.28 152.88 l f* 439.56 204.24 m 1 g 405.12 412.92 0.48 -0.06 re 323.16 249.24 l 207.24 566.16 l 200.93 559.44 194.64 565.784 194.64 573.6 c 170.16 267.48 l 452.28 374.16 l 177.48 655.44 6 -1.68 re S f* 369.48 572.4 0.48 -0.06 re 423.6 595.08 l 382.56 438.6 2.52 -0.06 re 1 g 162.6 257.04 1.56 -0.06 re 14.4 273.48 582.48 -5.4 re 398.88 163.68 l S 296.28 258.84 19.56 -9.36 re f* 202.8 141.84 m 405.348 600.72 413.52 592.602 413.52 582.6 c )Tj 180 302.28 0.72 -0.06 re f* 196.2 638.4 l 201.96 545.52 l 317.88 293.16 l 180.96 294.96 l 24 0 0 24 95.64 330.12 Tm 159.6 297.84 l 368.28 605.52 l f* 219.96 339.24 l 284.64 232.68 1.68 -0.06 re f* 0 -1.209 TD 453.24 578.28 l 153.36 400.92 7.2 -3 re 178.92 204.48 l 267.36 345.72 m 159.96 305.4 292.32 -18 re 149.04 268.92 l S S 257.16 408.24 l 509.04 423.24 0.84 -0.06 re 368.16 542.88 l 288.6 222.84 1.68 -0.06 re /F12 1 Tf 397.32 419.76 l 310.56 523.8 l 329.76 608.28 6 -3.36 re f* 322.68 529.2 l S 159.84 441.96 0.6 -0.06 re 438 243 l 243.36 625.68 l 342.96 224.88 l 304.56 526.92 l 389.76 268.2 l 177.12 216.6 l 261.24 566.16 l S 1 g f* 202.8 497.4 6 -1.8 re 446.76 253.2 l 395.88 218.16 l 424.56 533.76 l f* 216 442.08 l 437.52 415.68 0.6 -0.06 re 0000382269 00000 n 428.64 448.08 l 121.56 408.48 l f* f* 290.16 225.84 1.44 -0.06 re 334.08 592.366 341.714 600 351.12 600 c 342.36 155.88 m 222.72 264.72 l 428.76 437.76 l f* 158.16 460.56 l 384.48 265.32 l 272.4 583.44 m 177.48 257.52 6 -7.32 re 493.08 269.76 l 422.64 541.32 l 348.24 610.92 m 0.004 Tc 203.04 545.52 l 160.56 254.88 l 244.56 249.36 l 333.36 245.88 l 215.4 621.84 l 291.72 223.44 l 335.04 156 l 334.68 249.12 l 222.72 561.72 l f* f* 286.56 410.16 l S f* 347.88 298.8 l 152.16 638.64 l 350.88 268.44 l 279 638.16 l 514.32 259.32 l f* 513 93.96 l 408 167.76 m 392.52 262.68 l 146.04 415.44 l 192.96 299.64 l 0 Tc 152.16 297.48 6 -2.16 re /F8 1 Tf 208.32 565.8 l 407.16 595.44 m 158.16 267.24 l 420.48 222.72 l S 257.76 292.2 l 405.48 219.36 m 391.44 569.76 l 463.08 533.52 l 329.76 611.76 6 -1.56 re S 153.36 425.64 l 429.6 443.88 l 306.36 571.8 0.36 -0.06 re 360.48 615.96 l 233.04 545.64 l 348.36 556.32 l f* 354.96 309 l 330.48 245.28 l f* 291.12 185.52 l 349.44 231 l ET f* 384.12 265.56 l f* 392.88 561.36 l 220.92 625.32 l 418.8 204.48 l S 395.28 446.64 l 152.76 260.88 l f* 131.64 485.88 m S 253.32 554.64 l f* 419.28 440.28 0.48 -0.06 re 214.56 202.2 l 115.56 303.84 1.56 -0.06 re S 1 g S 394.44 552.6 l 0001332726 00000 n 184.56 606.36 m 372 303.72 0.96 -0.06 re 158.16 132 l 173.28 533.28 l 171.24 581.28 l 326.4 240 l 148.8 284.76 m 0.039 0.145 0.431 rg S 317.16 240.36 m 438.48 601.68 l 275.52 302.4 0.36 -0.06 re 367.56 233.76 l 272.16 135.48 l 204.24 580.68 m 1 i 1 J 1 j 0.96 w 10 M []0 d 164.88 660.48 l 443.64 580.56 l 164.88 97.32 6 -4.44 re 203.52 637.08 l (C)Tj 424.32 551.76 l 512.28 540.6 l 393 271.92 l 1 g 202.8 594.24 6 -3 re 208.8 135.12 l f* 455.76 409.92 l 322.92 566.16 l 164.88 514.56 m 405.48 549.36 l 205.32 261.48 l 498.96 423.72 0.84 -0.06 re 1 g f* 178.8 605.787 175.359 602.4 171.12 602.4 c 179.04 250.2 l 202.8 255.48 m 369.12 189.96 l f* f* 317.64 580.56 l 318.96 297.12 l 255.24 618.24 l 297.12 616.2 l (DNA)Tj 300.12 540.12 m 352.92 441.24 0.48 -0.06 re S 329.76 240.12 l 419.76 303 l 385.32 554.16 0.6 -0.06 re Q 448.8 543.24 l 177.6 204.96 l f* 152.28 457.68 l 128.16 52.32 l 470.52 296.64 l 291.12 512.4 l S f* 281.64 615.96 l S 218.16 287.64 l 333.36 562.2 l 152.52 81.48 l 154.08 33.6 l 317.4 520.44 l 414.72 435.6 l 339 253.32 l 322.2 626.64 l 374.28 420.84 l 323.52 235.32 l 385.56 427.92 l 218.16 313.56 l 368.16 540.84 l 280.2 156.6 l 412.08 577.49 405.736 571.2 397.92 571.2 c 296.4 150.12 l 320.4 255.6 l S f* 452.28 306.84 l 165.6 126 l 0 G 183.48 248.28 l 131.64 489.96 l 216.96 204.48 m 335.04 238.56 l 163.68 555.72 l 304.56 235.08 m 366.36 233.4 l 251.16 408.84 l S 183.48 277.56 l S 153 266.16 l 146.04 412.92 l 1 i 1 J 1 j 0.96 w 10 M []0 d 318.36 264.72 l 203.64 577.8 l 266.16 517.44 m 329.76 238.08 6 -1.2 re 443.76 189.96 l ( 61 ccagggctgg gcataaaagt cagggcagag ccatctattg ctt)Tj 203.88 568.2 l 278.52 624.84 l 443.88 528.36 l 322.56 357.96 l 221.4 510.6 l 284.64 532.68 l 177.48 543 6 -2.28 re 0 g W n 0 J 0 j 216 444.96 l 234.36 33.6 l f* 469.92 561.12 l 484.44 361.08 l /F12 1 Tf f* S 439.68 151.08 l 334.32 573.36 0.72 -0.06 re f* 249.96 630 l 495.48 424.56 0.96 -0.06 re 449.64 544.32 l f* 443.52 243 l 218.16 381.24 l 342.96 580.56 m 342 302.76 0.48 -0.06 re 206.28 571.56 l 425.64 399.36 l 234.24 477.24 m 440.64 527.28 l 279.36 254.28 m 408.6 595.44 l 208.8 652.56 l 386.28 224.16 l 456.36 570.12 l 0 g 386.28 189.48 l 164.88 680.88 l 1 g 183.48 583.32 l S 127.68 441.36 0.48 -0.06 re 344.88 603 l 323.04 148.92 l 202.44 449.28 l 439.68 580.68 l 431.04 558.48 m 528.96 526.68 l 190.68 565.8 m S 203.28 510.24 l f* 393 252.6 l 153.36 407.28 m S f* 266.16 635.16 l 152.16 673.56 6 -2.04 re f* 0 g 422.64 351.72 l f* 390.96 435.24 m f* 97.8 238.92 l 153.36 360.12 m 0.039 0.145 0.431 rg 1 g 319.2 233.88 l f* 372.6 304.08 0.72 -0.06 re 215.76 444 l 414.48 310.08 l 227.88 225 l 308.28 571.68 1.08 -0.06 re 232.56 580.68 l 423.48 552.6 m 405.6 204.84 l 509.64 450.96 0.84 -0.06 re 403.8 551.16 l 423.48 540.84 m f* f* 242.64 527.28 l Academia.edu no longer supports Internet Explorer. 196.56 593.76 l 253.8 440.88 0.48 -0.06 re f* 451.68 436.2 l 589.8 233.88 l 246.6 581.28 l 494.88 397.68 0.84 -0.06 re 383.4 613.68 l 454.44 235.2 l 427.32 524.64 l S 322.8 248.053 316.188 241.44 308.04 241.44 c f* 1 g 409.2 604.92 l 177.108 624 185.28 615.936 185.28 606 c 0 G 444.12 556.08 l 14.4 225.36 582.48 -5.4 re 342.36 186.96 6 -2.52 re S 152.88 255.72 1.8 -0.06 re 120.96 409.68 l 447 468.84 l 422.76 566.16 l 355.08 239.64 l 0000405863 00000 n 403.44 411.96 l 208.8 119.52 l 201.72 493.2 m -0.003 Tw 160.08 254.4 l 197.16 444.96 l 190.2 205.08 l BT /F8 1 Tf f* 179.88 314.76 l 166.08 444.48 l 125.28 426.72 l S 283.56 297.24 l 152.16 650.52 6 -5.88 re f* 183.48 660.24 l 166.08 447.48 l 444 565.92 l 177.48 491.4 l f* 218.16 343.32 l 165.12 268.2 l 323.52 254.64 m 280.08 566.16 m (gly)Tj 202.8 558.36 l (The )Tj 202.8 555.6 l 1 i 1 J 1 j 0.96 w 10 M []0 d 0 g f* 363.48 243.6 l 196.2 508.8 m 344.28 573.36 0.36 -0.06 re 214.44 255.48 l f* 208.8 259.44 l 418.08 266.4 l f* 0.035 0.129 0.384 rg 136.08 444.72 l 380.16 410.28 l 215.64 277.2 l 299.28 318.95 303.903 323.52 309.6 323.52 c f* 1 g 308.88 204.6 m 1 i 1 J 1 j 0.96 w 10 M []0 d 200.16 282.046 207.794 289.68 217.2 289.68 c f* 292.68 148.56 l 473.4 416.04 0.6 -0.06 re f* ET 342.36 155.88 l 190.2 550.68 l 160.32 298.2 l 120.96 263.28 l 401.04 572.76 l 468 556.2 l 320.16 644.4 l 495.48 309.72 0.96 -0.06 re 348.12 189.96 l f* 330.72 248.76 l 283.08 566.16 l 14.4 513.36 582.48 -5.4 re 386.28 173.28 l 0 g 1 g S 177.48 538.44 m f* 396.6 574.56 1.32 -0.06 re 258.12 256.8 l 329.88 204.6 l 291.12 154.32 6 -3.72 re f* 206.76 637.56 l f* f* 369.48 574.08 0.48 -0.06 re 310.56 152.88 m f* 365.64 564.6 l RNA molecules fall into)]TJ 387.12 363.24 l 315.6 298.44 l 120.96 289.32 l S 14.4 207.36 582.48 -5.4 re 359.16 540.36 l [(hem)8(ophi)-15(li)-14(a)]TJ 248.88 624.84 l 496.44 265.2 l 330.24 435.12 l 198.84 436.32 l 196.2 177.24 l -53.731 0 TD 215.4 650.76 m S f* S 291.12 173.52 m 259.32 622.68 l 455.16 549.24 l 444.12 522.48 l 165.36 503.64 l S 152.16 240.24 6 -3 re 353.52 223.92 2.52 -0.06 re f* 202.8 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